Spinal cord compression secondary to extramedullary hematopoiesis in thalassemia intermedia

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Spinal cord compression due to intraspinal extramedullary hematopoiesis in thalassemia intermedia.

Extramedullary hematopoiesis is a common phenomenon in thalassemia. During the disease there are very rare occasions when compensatory hematopoietic tissue is located in the intraspinal epidural space, causing spinal cord compression. This complication requires urgent neurosurgical consideration and decision for further treatment. We present a case of thoracic spinal cord compression secondary ...

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Thalassemia, extramedullary hematopoiesis, and spinal cord compression: A case report

BACKGROUND Extramedullary hematopoiesis (EMH) refers to hematopoiesis outside of the medulla of the bone. Chronic anemia states such as thalassemia can cause hematopoietic tissue to expand in certain locations. We report a case of spinal cord compression due to recurrent spinal epidural EMH, which was treated with a combination of surgery and radiotherapy. Pakistan has one of the highest incide...

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Cord Compression Due to Extramedullary Hematopoiesis in Two Patients of ß-thalassemia Intermedia

Thalassemia is the most important hemoglobinopathy in Khuzestan province. Thalassemia intermedia (TI) is a genetically heterogenous disease and can result from many different genetic lesions. We report two cases of TI-EMH caused by two separate mechanism and their successful management. Magnetic Resonance Imaging (MRI) is the best diagnostic method in these cases. Management can be done via: Tr...

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MR of extramedullary hematopoiesis causing cord compression in beta-thalassemia.

A 30-year-old woman presented with back pain, weakness and numbness in both lower extremities, and difficulty initiating voiding. The patient was diagnosed at age 3 with beta-thalassemia intermedia. Physical examination revealed frontal bossing, a prominent mandible, T 4-level tenderness, decreased strength, light touch, pin prick and temperature in both lower extremities, abdomen and back with...

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Extramedullary hematopoiesis (EMH) is a physiological compensatory phenomenon occurring in many hemolytic anemias including thalassemia. Besides transfusion, radiotherapy, surgery or a combination of these modalities, hydroxyurea (HU) as an optimal treatment has been described occasionally. We described a case of beta-thalassemia major who has been on regular blood transfusion and developed EMH...

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ژورنال

عنوان ژورنال: European Spine Journal

سال: 1998

ISSN: 0940-6719,1432-0932

DOI: 10.1007/s005860050114